Drug interactions
Belladonna and opium + Tranylcypromine
Severity: Major
Belladonna and opium and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component is an opioid, and combining it with an MAO inhibitor can cause excessive sedation, respiratory depression, blood pressure instability and in some cases serotonin syndrome. The belladonna alkaloids add anticholinergic effects that MAOIs may prolong and intensify.
What this interaction means in plain words
Belladonna and opium and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition can enhance opioid CNS effects and serotonergic activity, with additive anticholinergic effects from belladonna.
What to do
Avoid the combination during tranylcypromine therapy and for 14 days after discontinuation; use a non-opioid alternative. If it cannot be avoided, give minimal doses and monitor sedation, respiration, blood pressure and temperature.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Tranylcypromine?
MediHelp rates the interaction as major. Belladonna and opium and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component is an opioid, and combining it with an MAO inhibitor can cause excessive sedation, respiratory depression, blood pressure instability and in some cases serotonin syndrome. The belladonna alkaloids add anticholinergic effects that MAOIs may prolong and intensify.
How serious is the interaction between Belladonna and opium and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during tranylcypromine therapy and for 14 days after discontinuation; use a non-opioid alternative. If it cannot be avoided, give minimal doses and monitor sedation, respiration, blood pressure and temperature.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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