Drug interactions
Belladonna and opium + Ziprasidone
Severity: Moderate
Belladonna and opium and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds opioid sedation and respiratory depression, while the belladonna component adds anticholinergic effects. With ziprasidone this can increase drowsiness, hypotension, constipation and urinary retention.
What this interaction means in plain words
Belladonna and opium and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and antipsychotic activity plus additive antimuscarinic effects.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Ziprasidone?
MediHelp rates the interaction as moderate. Belladonna and opium and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component adds opioid sedation and respiratory depression, while the belladonna component adds anticholinergic effects. With ziprasidone this can increase drowsiness, hypotension, constipation and urinary retention.
How serious is the interaction between Belladonna and opium and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Counsel patients to avoid driving and alcohol.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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