Drug interactions
Belzutifan + Deflazacort
Severity: Moderate
Belzutifan and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and can lower exposure to the active metabolite of deflazacort. This may reduce steroid efficacy in conditions such as Duchenne muscular dystrophy.
What this interaction means in plain words
Belzutifan and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Deflazacort belongs to Miscellaneous.
Why it happens
Belzutifan induces CYP3A4, increasing the clearance of deflazacort's active metabolite.
What to do
Monitor clinical response and consider a higher deflazacort dose if effect is lost; reassess when belzutifan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Deflazacort?
MediHelp rates the interaction as moderate. Belzutifan and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and can lower exposure to the active metabolite of deflazacort. This may reduce steroid efficacy in conditions such as Duchenne muscular dystrophy.
How serious is the interaction between Belzutifan and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider a higher deflazacort dose if effect is lost; reassess when belzutifan is stopped.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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