Drug interactions
Belzutifan + Diazepam
Severity: Moderate
Belzutifan and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may lower diazepam concentrations, potentially reducing its anxiolytic, anticonvulsant or sedative effect. The effect is likely modest for diazepam given its additional CYP2C19 pathway.
What this interaction means in plain words
Belzutifan and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Diazepam belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by belzutifan increases diazepam metabolism.
What to do
Monitor clinical response to diazepam and increase the dose if effect is reduced. Reassess dose when belzutifan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Diazepam?
MediHelp rates the interaction as moderate. Belzutifan and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may lower diazepam concentrations, potentially reducing its anxiolytic, anticonvulsant or sedative effect. The effect is likely modest for diazepam given its additional CYP2C19 pathway.
How serious is the interaction between Belzutifan and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to diazepam and increase the dose if effect is reduced. Reassess dose when belzutifan is stopped.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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