Drug interactions
Belzutifan + Erythromycin
Severity: Moderate
Belzutifan and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is a CYP3A4 inducer and may lower erythromycin exposure, potentially reducing antibacterial effect.
What this interaction means in plain words
Belzutifan and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 increases erythromycin metabolism.
What to do
Monitor for reduced antibiotic response, or choose an antibiotic not dependent on CYP3A4 such as azithromycin. Increase the dose only if clinically needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belzutifan and Erythromycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Erythromycin?
MediHelp rates the interaction as moderate. Belzutifan and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is a CYP3A4 inducer and may lower erythromycin exposure, potentially reducing antibacterial effect.
How serious is the interaction between Belzutifan and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antibiotic response, or choose an antibiotic not dependent on CYP3A4 such as azithromycin. Increase the dose only if clinically needed.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
