Drug interactions
Belzutifan + Irinotecan
Severity: Moderate
Belzutifan and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Irinotecan is converted to its active metabolite SN-38, and CYP3A4 also forms inactive metabolites, so net effect on efficacy and toxicity is uncertain.
What this interaction means in plain words
Belzutifan and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Irinotecan belongs to Oncology.
Why it happens
CYP3A4 induction by belzutifan alters irinotecan metabolism and may change SN-38 exposure.
What to do
Monitor for reduced response and for toxicity such as diarrhoea and neutropenia, and review the regimen if the response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Irinotecan?
MediHelp rates the interaction as moderate. Belzutifan and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Irinotecan is converted to its active metabolite SN-38, and CYP3A4 also forms inactive metabolites, so net effect on efficacy and toxicity is uncertain.
How serious is the interaction between Belzutifan and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and for toxicity such as diarrhoea and neutropenia, and review the regimen if the response is poor.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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