Drug interactions
Benazepril + Bendroflumethiazide
Severity: Moderate
Benazepril and Bendroflumethiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination is commonly used for hypertension and gives additive blood pressure reduction. Volume depletion from the diuretic can cause first-dose hypotension and renal function decline when benazepril is started.
What this interaction means in plain words
Benazepril and Bendroflumethiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects from diuretic-induced volume depletion and renin-angiotensin system blockade.
What to do
Start benazepril at a low dose in patients on a diuretic, or temporarily reduce the diuretic. Monitor blood pressure, creatinine and electrolytes after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Bendroflumethiazide?
MediHelp rates the interaction as moderate. Benazepril and Bendroflumethiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination is commonly used for hypertension and gives additive blood pressure reduction. Volume depletion from the diuretic can cause first-dose hypotension and renal function decline when benazepril is started.
How serious is the interaction between Benazepril and Bendroflumethiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start benazepril at a low dose in patients on a diuretic, or temporarily reduce the diuretic. Monitor blood pressure, creatinine and electrolytes after initiation.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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