Drug interactions
Benazepril + Bretylium
Severity: Moderate
Benazepril and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium can cause significant hypotension through adrenergic neuron blockade, and benazepril adds to blood pressure lowering. The combination may produce pronounced or symptomatic hypotension.
What this interaction means in plain words
Benazepril and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from sympathetic neuron blockade and ACE inhibition.
What to do
Monitor blood pressure closely during bretylium use and consider temporarily withholding benazepril in unstable patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Bretylium?
MediHelp rates the interaction as moderate. Benazepril and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium can cause significant hypotension through adrenergic neuron blockade, and benazepril adds to blood pressure lowering. The combination may produce pronounced or symptomatic hypotension.
How serious is the interaction between Benazepril and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during bretylium use and consider temporarily withholding benazepril in unstable patients.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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