Drug interactions
Benazepril + Butabarbital
Severity: Moderate
Benazepril and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can cause hypotension and may enhance the blood-pressure-lowering effect of antihypertensives such as benazepril. The effect is generally modest but may cause dizziness or falls, particularly in older adults.
What this interaction means in plain words
Benazepril and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from barbiturate CNS-mediated vasomotor depression and ACE inhibition.
What to do
Monitor blood pressure when starting or changing the barbiturate dose. Counsel on orthostatic precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Butabarbital?
MediHelp rates the interaction as moderate. Benazepril and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can cause hypotension and may enhance the blood-pressure-lowering effect of antihypertensives such as benazepril. The effect is generally modest but may cause dizziness or falls, particularly in older adults.
How serious is the interaction between Benazepril and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or changing the barbiturate dose. Counsel on orthostatic precautions.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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