Drug interactions
Benazepril + Butalbital
Severity: Minor
Benazepril and Butalbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may add to the blood-pressure-lowering effect of benazepril. The effect is usually modest and the interaction is poorly documented.
What this interaction means in plain words
Benazepril and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypotension from barbiturate CNS depression; not firmly established.
What to do
Monitor blood pressure if butalbital is used regularly and counsel patients about dizziness on standing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Butalbital?
MediHelp rates the interaction as minor. Benazepril and Butalbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may add to the blood-pressure-lowering effect of benazepril. The effect is usually modest and the interaction is poorly documented.
How serious is the interaction between Benazepril and Butalbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if butalbital is used regularly and counsel patients about dizziness on standing.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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