Drug interactions
Benazepril + Conivaptan
Severity: Moderate
Benazepril and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan causes aquaresis, and rapid fluid loss may lead to hypovolemia and hypotension. With benazepril, hypotension and renal function decline are more likely.
What this interaction means in plain words
Benazepril and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Vasopressin V1a/V2 antagonism causing free-water loss and volume depletion adds to ACE inhibitor hypotensive effects.
What to do
Monitor blood pressure, volume status, serum sodium and renal function during conivaptan therapy. Consider holding benazepril if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Conivaptan?
MediHelp rates the interaction as moderate. Benazepril and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan causes aquaresis, and rapid fluid loss may lead to hypovolemia and hypotension. With benazepril, hypotension and renal function decline are more likely.
How serious is the interaction between Benazepril and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, serum sodium and renal function during conivaptan therapy. Consider holding benazepril if hypotension or volume depletion develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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