Drug interactions
Benazepril + Empagliflozin-linagliptin
Severity: Moderate
Benazepril and Empagliflozin-linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
What this interaction means in plain words
Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Empagliflozin-linagliptin belongs to Endocrine.
Why it happens
Additive reduction in bradykinin and substance P degradation through ACE and DPP-4 inhibition.
What to do
Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
How serious is the interaction between Benazepril and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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