Drug interactions
Benazepril + Ferric gluconate
Severity: Minor
Benazepril and Ferric gluconate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous iron can occasionally cause infusion-related hypersensitivity reactions and hypotension. ACE inhibitors have been reported to increase the severity of such reactions with intravenous iron, though the evidence is limited.
What this interaction means in plain words
Benazepril and Ferric gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not well established; ACE inhibition may impair compensation for iron-related vasodilatory reactions through reduced angiotensin II and altered bradykinin breakdown.
What to do
Give ferric gluconate by slow infusion with blood pressure monitoring. No routine change to benazepril is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Ferric gluconate?
MediHelp rates the interaction as minor. Benazepril and Ferric gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intravenous iron can occasionally cause infusion-related hypersensitivity reactions and hypotension. ACE inhibitors have been reported to increase the severity of such reactions with intravenous iron, though the evidence is limited.
How serious is the interaction between Benazepril and Ferric gluconate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give ferric gluconate by slow infusion with blood pressure monitoring. No routine change to benazepril is needed.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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