Drug interactions
Benazepril + Glimepiride-pioglitazone
Severity: Moderate
Benazepril and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been associated with hypoglycemia in patients on sulfonylureas such as glimepiride.
What this interaction means in plain words
Benazepril and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Additive glucose lowering through enhanced insulin sensitivity, possibly via bradykinin effects.
What to do
Monitor blood glucose when starting benazepril, especially in the first weeks, and reduce glimepiride if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Benazepril and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been associated with hypoglycemia in patients on sulfonylureas such as glimepiride.
How serious is the interaction between Benazepril and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting benazepril, especially in the first weeks, and reduce glimepiride if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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