Drug interactions
Benazepril + Gold sodium thiomalate
Severity: Moderate
Benazepril and Gold sodium thiomalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rare nitritoid reactions have been reported with injectable gold in patients taking ACE inhibitors. These include facial flushing, nausea, vomiting and hypotension, usually shortly after the gold injection.
What this interaction means in plain words
Benazepril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thought to involve vasodilatory effects of gold combined with reduced breakdown of vasoactive kinins during ACE inhibition, although the mechanism is not fully established.
What to do
Monitor patients for flushing and hypotension after each injection. If reactions recur, consider alternative antihypertensive therapy or a different disease-modifying agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benazepril and Gold sodium thiomalate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Gold sodium thiomalate?
MediHelp rates the interaction as moderate. Benazepril and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rare nitritoid reactions have been reported with injectable gold in patients taking ACE inhibitors. These include facial flushing, nausea, vomiting and hypotension, usually shortly after the gold injection.
How serious is the interaction between Benazepril and Gold sodium thiomalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for flushing and hypotension after each injection. If reactions recur, consider alternative antihypertensive therapy or a different disease-modifying agent.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
