Drug interactions
Benazepril + Heparin
Severity: Moderate
Benazepril and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress adrenal aldosterone production, and ACE inhibitors also reduce aldosterone effects. The combination may cause hyperkalemia, particularly in patients with renal impairment, diabetes or prolonged heparin use.
What this interaction means in plain words
Benazepril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone-mediated potassium excretion.
What to do
Monitor serum potassium during combined therapy, especially if heparin continues beyond several days or renal function is reduced. Treat hyperkalemia if it occurs and reassess the need for each drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Benazepril with Heparin?
MediHelp rates the interaction as moderate. Benazepril and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress adrenal aldosterone production, and ACE inhibitors also reduce aldosterone effects. The combination may cause hyperkalemia, particularly in patients with renal impairment, diabetes or prolonged heparin use.
How serious is the interaction between Benazepril and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during combined therapy, especially if heparin continues beyond several days or renal function is reduced. Treat hyperkalemia if it occurs and reassess the need for each drug.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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