Drug interactions
Benazepril + Indapamide
Severity: Moderate
Benazepril and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination lowers blood pressure more than either drug alone, which is often intended. In volume-depleted patients, first doses or dose increases can cause symptomatic hypotension and acute kidney injury.
What this interaction means in plain words
Benazepril and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from diuretic volume depletion and ACE inhibition, which reduces efferent arteriolar tone and glomerular filtration pressure.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing doses. Consider reducing or temporarily holding indapamide before starting benazepril in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Indapamide?
MediHelp rates the interaction as moderate. Benazepril and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination lowers blood pressure more than either drug alone, which is often intended. In volume-depleted patients, first doses or dose increases can cause symptomatic hypotension and acute kidney injury.
How serious is the interaction between Benazepril and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing doses. Consider reducing or temporarily holding indapamide before starting benazepril in volume-depleted patients.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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