Drug interactions
Benazepril + Iron dextran complex
Severity: Major
Benazepril and Iron dextran complex: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients taking ACE inhibitors have been reported to have more severe anaphylactoid reactions to parenteral iron dextran. Iron dextran itself carries a boxed warning for anaphylaxis.
What this interaction means in plain words
Benazepril and Iron dextran complex can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Not firmly established; ACE inhibition may impair bradykinin breakdown and compensatory responses during anaphylactoid reactions.
What to do
Prefer an alternative IV iron product, or temporarily hold the ACE inhibitor if clinically feasible. If iron dextran is given, administer a test dose and observe with resuscitation facilities available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Iron dextran complex?
MediHelp rates the interaction as major. Benazepril and Iron dextran complex can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Patients taking ACE inhibitors have been reported to have more severe anaphylactoid reactions to parenteral iron dextran. Iron dextran itself carries a boxed warning for anaphylaxis.
How serious is the interaction between Benazepril and Iron dextran complex?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative IV iron product, or temporarily hold the ACE inhibitor if clinically feasible. If iron dextran is given, administer a test dose and observe with resuscitation facilities available.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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