Drug interactions
Benazepril + Metformin-sitagliptin
Severity: Moderate
Benazepril and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors such as sitagliptin may increase the risk of angioedema in patients taking ACE inhibitors. ACE inhibitors may also enhance glucose lowering and slightly affect metformin safety in renal impairment.
What this interaction means in plain words
Benazepril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Both ACE inhibitors and DPP-4 inhibitors reduce substance P and bradykinin breakdown, so angioedema risk is additive; the glucose effect is pharmacodynamic.
What to do
Counsel the patient to report lip, tongue or facial swelling promptly. Monitor blood glucose and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Benazepril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as sitagliptin may increase the risk of angioedema in patients taking ACE inhibitors. ACE inhibitors may also enhance glucose lowering and slightly affect metformin safety in renal impairment.
How serious is the interaction between Benazepril and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report lip, tongue or facial swelling promptly. Monitor blood glucose and renal function.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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