Drug interactions
Benazepril + Metformin
Severity: Minor
Benazepril and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may modestly improve glycemic control and occasionally increase hypoglycemia risk when used with antidiabetic drugs, though metformin alone rarely causes hypoglycemia. Acute kidney injury from an ACE inhibitor could indirectly reduce metformin clearance and raise lactic acidosis risk.
What this interaction means in plain words
Benazepril and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Possible improved insulin sensitivity; renal impairment related to ACE inhibition could reduce metformin elimination.
What to do
Monitor blood glucose and renal function periodically. Hold metformin if acute kidney injury or dehydration develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Metformin
Frequently asked questions
Can I take Benazepril with Metformin?
MediHelp rates the interaction as minor. Benazepril and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may modestly improve glycemic control and occasionally increase hypoglycemia risk when used with antidiabetic drugs, though metformin alone rarely causes hypoglycemia. Acute kidney injury from an ACE inhibitor could indirectly reduce metformin clearance and raise lactic acidosis risk.
How serious is the interaction between Benazepril and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function periodically. Hold metformin if acute kidney injury or dehydration develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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