Drug interactions
Benazepril + Methyclothiazide
Severity: Moderate
Benazepril and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics are commonly combined with ACE inhibitors for additive blood pressure control. First-dose hypotension and reduced renal function can occur, especially in patients who are volume depleted.
What this interaction means in plain words
Benazepril and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced sodium and volume depletion activates the renin-angiotensin system, so ACE inhibition produces an exaggerated fall in blood pressure and glomerular filtration.
What to do
Start benazepril at a low dose in patients on diuretics and monitor blood pressure, creatinine and electrolytes during the first weeks. Consider reducing the diuretic dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Methyclothiazide?
MediHelp rates the interaction as moderate. Benazepril and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics are commonly combined with ACE inhibitors for additive blood pressure control. First-dose hypotension and reduced renal function can occur, especially in patients who are volume depleted.
How serious is the interaction between Benazepril and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start benazepril at a low dose in patients on diuretics and monitor blood pressure, creatinine and electrolytes during the first weeks. Consider reducing the diuretic dose if hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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