Drug interactions
Benazepril + Nitroprusside
Severity: Moderate
Benazepril and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so giving them together can produce a deeper fall in pressure than either alone. This is most relevant during nitroprusside infusion in patients already taking an ACE inhibitor.
What this interaction means in plain words
Benazepril and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and reduced angiotensin II-mediated vasoconstriction produce pharmacodynamic synergism on blood pressure.
What to do
Titrate the nitroprusside infusion with continuous blood pressure monitoring and use lower starting rates in patients on benazepril. Be ready to reduce or stop the infusion if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Nitroprusside?
MediHelp rates the interaction as moderate. Benazepril and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so giving them together can produce a deeper fall in pressure than either alone. This is most relevant during nitroprusside infusion in patients already taking an ACE inhibitor.
How serious is the interaction between Benazepril and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the nitroprusside infusion with continuous blood pressure monitoring and use lower starting rates in patients on benazepril. Be ready to reduce or stop the infusion if hypotension develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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