Drug interactions
Benazepril + Olanzapine
Severity: Moderate
Benazepril and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension. Combined with benazepril, blood pressure lowering may be enhanced, particularly at treatment initiation or dose increases.
What this interaction means in plain words
Benazepril and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Olanzapine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism by olanzapine and ACE inhibition by benazepril.
What to do
Monitor orthostatic blood pressure when starting or increasing either drug, and counsel patients to rise slowly. Adjust the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Benazepril with Olanzapine?
MediHelp rates the interaction as moderate. Benazepril and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension. Combined with benazepril, blood pressure lowering may be enhanced, particularly at treatment initiation or dose increases.
How serious is the interaction between Benazepril and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or increasing either drug, and counsel patients to rise slowly. Adjust the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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