Drug interactions
Benazepril + Pentobarbital
Severity: Moderate
Benazepril and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital may add to the blood pressure lowering of benazepril and cause hypotension, particularly orthostatic hypotension. The effect is more likely with parenteral or high doses and in volume-depleted patients.
What this interaction means in plain words
Benazepril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-induced central nervous system depression and vasodilation add to the antihypertensive effect of ACE inhibition.
What to do
Monitor blood pressure when pentobarbital is started or the dose increased, and counsel the patient to rise slowly. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Pentobarbital?
MediHelp rates the interaction as moderate. Benazepril and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital may add to the blood pressure lowering of benazepril and cause hypotension, particularly orthostatic hypotension. The effect is more likely with parenteral or high doses and in volume-depleted patients.
How serious is the interaction between Benazepril and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when pentobarbital is started or the dose increased, and counsel the patient to rise slowly. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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