Drug interactions
Benazepril + Potassium acid
Severity: Major
Benazepril and Potassium acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce aldosterone and potassium excretion, so potassium supplements such as potassium acid phosphate can cause hyperkalemia. The risk is greater with renal impairment, diabetes, advanced age or other potassium-raising drugs.
What this interaction means in plain words
Benazepril and Potassium acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
ACE inhibition lowers aldosterone-mediated renal potassium excretion while the supplement adds a potassium load.
What to do
Avoid routine co-prescription unless hypokalemia is documented, and check serum potassium and renal function within the first week and periodically afterwards. Reduce or stop the potassium if levels rise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Potassium acid?
MediHelp rates the interaction as major. Benazepril and Potassium acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors reduce aldosterone and potassium excretion, so potassium supplements such as potassium acid phosphate can cause hyperkalemia. The risk is greater with renal impairment, diabetes, advanced age or other potassium-raising drugs.
How serious is the interaction between Benazepril and Potassium acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-prescription unless hypokalemia is documented, and check serum potassium and renal function within the first week and periodically afterwards. Reduce or stop the potassium if levels rise.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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