Drug interactions
Benazepril + Potassium citrate-citric acid
Severity: Moderate
Benazepril and Potassium citrate-citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors lower aldosterone and decrease renal potassium loss, and potassium citrate adds potassium. The combination can result in hyperkalemia, particularly in patients with kidney disease, diabetes or heart failure.
What this interaction means in plain words
Benazepril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Potassium citrate-citric acid belongs to Gastrointestinal Tract.
Why it happens
ACE inhibition reduces angiotensin II-driven aldosterone secretion, decreasing renal potassium excretion on top of a supplemental potassium load.
What to do
Monitor serum potassium and renal function at baseline, after initiation and periodically. Lower or stop potassium citrate if potassium becomes elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benazepril and Potassium citrate-citric acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Potassium citrate-citric acid
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Potassium citrate-citric acid?
MediHelp rates the interaction as moderate. Benazepril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors lower aldosterone and decrease renal potassium loss, and potassium citrate adds potassium. The combination can result in hyperkalemia, particularly in patients with kidney disease, diabetes or heart failure.
How serious is the interaction between Benazepril and Potassium citrate-citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at baseline, after initiation and periodically. Lower or stop potassium citrate if potassium becomes elevated.
What other medicines interact with Potassium citrate-citric acid?
MediHelp also lists interactions of Potassium citrate-citric acid with, for example, Amiloride, Eplerenone, Finerenone. The full list is on the Potassium citrate-citric acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
