Drug interactions
Benazepril + Potassium phosphates
Severity: Major
Benazepril and Potassium phosphates: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous potassium phosphates deliver a rapid potassium load, and benazepril limits the kidney's ability to excrete it. This increases the risk of hyperkalemia and cardiac arrhythmias.
What this interaction means in plain words
Benazepril and Potassium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
ACE inhibition decreases aldosterone-mediated potassium excretion, compounding the administered potassium load.
What to do
Dose potassium phosphates according to measured serum potassium, phosphate and renal function, with serial laboratory checks during infusion. Consider holding benazepril in acute settings if hyperkalemia risk is high.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Potassium phosphates?
MediHelp rates the interaction as major. Benazepril and Potassium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous potassium phosphates deliver a rapid potassium load, and benazepril limits the kidney's ability to excrete it. This increases the risk of hyperkalemia and cardiac arrhythmias.
How serious is the interaction between Benazepril and Potassium phosphates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose potassium phosphates according to measured serum potassium, phosphate and renal function, with serial laboratory checks during infusion. Consider holding benazepril in acute settings if hyperkalemia risk is high.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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