Drug interactions
Benazepril + Promazine
Severity: Moderate
Benazepril and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine, a phenothiazine with alpha-adrenergic blocking activity, can cause orthostatic hypotension. With benazepril, blood pressure lowering may be enhanced, especially at treatment start or after dose increases.
What this interaction means in plain words
Benazepril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from alpha-1 blockade by the phenothiazine and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting promazine; reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Promazine?
MediHelp rates the interaction as moderate. Benazepril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine, a phenothiazine with alpha-adrenergic blocking activity, can cause orthostatic hypotension. With benazepril, blood pressure lowering may be enhanced, especially at treatment start or after dose increases.
How serious is the interaction between Benazepril and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting promazine; reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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