Drug interactions
Benazepril + Remifentanil
Severity: Minor
Benazepril and Remifentanil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remifentanil can lower blood pressure and heart rate, and the effect may add to the antihypertensive action of benazepril. Hypotension is more likely during anesthesia, particularly in volume-depleted patients.
What this interaction means in plain words
Benazepril and Remifentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from opioid-induced vasodilation and bradycardia combined with ACE inhibition.
What to do
Monitor blood pressure during remifentanil administration and treat hypotension with fluids or vasopressors if needed. Consider holding the ACE inhibitor on the morning of surgery according to local protocol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Remifentanil?
MediHelp rates the interaction as minor. Benazepril and Remifentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Remifentanil can lower blood pressure and heart rate, and the effect may add to the antihypertensive action of benazepril. Hypotension is more likely during anesthesia, particularly in volume-depleted patients.
How serious is the interaction between Benazepril and Remifentanil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during remifentanil administration and treat hypotension with fluids or vasopressors if needed. Consider holding the ACE inhibitor on the morning of surgery according to local protocol.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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