Drug interactions
Benazepril + Sildenafil
Severity: Moderate
Benazepril and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil can add to the blood pressure lowering effect of ACE inhibitors such as benazepril. This may cause symptomatic hypotension, especially after initiation or dose increases.
What this interaction means in plain words
Benazepril and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilation and hypotension from PDE5 inhibition plus ACE inhibition.
What to do
Start with a low sildenafil dose and monitor blood pressure and symptoms of dizziness. Advise patients to report fainting or lightheadedness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Sildenafil?
MediHelp rates the interaction as moderate. Benazepril and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sildenafil can add to the blood pressure lowering effect of ACE inhibitors such as benazepril. This may cause symptomatic hypotension, especially after initiation or dose increases.
How serious is the interaction between Benazepril and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low sildenafil dose and monitor blood pressure and symptoms of dizziness. Advise patients to report fainting or lightheadedness.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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