Drug interactions
Benazepril + Sodium nitroprusside
Severity: Moderate
Benazepril and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors add to the blood pressure lowering effect of nitroprusside. The hypotensive response may be greater than anticipated, particularly with volume depletion.
What this interaction means in plain words
Benazepril and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive hypotension from reduced angiotensin II and direct nitric oxide-mediated vasodilation.
What to do
Monitor blood pressure continuously and titrate the nitroprusside infusion carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Benazepril and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors add to the blood pressure lowering effect of nitroprusside. The hypotensive response may be greater than anticipated, particularly with volume depletion.
How serious is the interaction between Benazepril and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously and titrate the nitroprusside infusion carefully.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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