Drug interactions
Benazepril + Sodium phosphates
Severity: Major
Benazepril and Sodium phosphates: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral sodium phosphate bowel preparations can cause acute phosphate nephropathy, and ACE inhibitors increase susceptibility, particularly with dehydration. This may lead to acute or permanent kidney injury.
What this interaction means in plain words
Benazepril and Sodium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Phosphate load causes tubular calcium phosphate deposition, and ACE inhibitors reduce glomerular perfusion pressure, increasing renal vulnerability.
What to do
Avoid sodium phosphate bowel preparations in patients on ACE inhibitors and use a polyethylene glycol preparation instead. If unavoidable, ensure hydration and check renal function afterwards.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Sodium phosphates?
MediHelp rates the interaction as major. Benazepril and Sodium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral sodium phosphate bowel preparations can cause acute phosphate nephropathy, and ACE inhibitors increase susceptibility, particularly with dehydration. This may lead to acute or permanent kidney injury.
How serious is the interaction between Benazepril and Sodium phosphates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sodium phosphate bowel preparations in patients on ACE inhibitors and use a polyethylene glycol preparation instead. If unavoidable, ensure hydration and check renal function afterwards.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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