Drug interactions
Benazepril + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Benazepril and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid loss and electrolyte shifts, and with an ACE inhibitor this raises the risk of acute kidney injury and electrolyte disturbance. Volume depletion also increases the chance of hypotension.
What this interaction means in plain words
Benazepril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep-induced volume depletion reduces renal perfusion, which is poorly tolerated with ACE inhibition that impairs efferent arteriolar tone; the potassium content adds to hyperkalemia risk.
What to do
Ensure adequate hydration and consider withholding benazepril on the day of the preparation in patients at risk of kidney injury. Check renal function and electrolytes afterward in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Benazepril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations cause fluid loss and electrolyte shifts, and with an ACE inhibitor this raises the risk of acute kidney injury and electrolyte disturbance. Volume depletion also increases the chance of hypotension.
How serious is the interaction between Benazepril and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider withholding benazepril on the day of the preparation in patients at risk of kidney injury. Check renal function and electrolytes afterward in high-risk patients.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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