Drug interactions
Benazepril + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel cleansing causes fluid and electrolyte losses, which with an ACE inhibitor increases the risk of acute kidney injury and hypotension. Electrolyte disturbances may also contribute to arrhythmia.
What this interaction means in plain words
Benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion from the bowel preparation reduces renal perfusion, which is poorly tolerated during ACE inhibition.
What to do
Encourage adequate fluid intake before and after the preparation and consider holding benazepril on the day of use in at-risk patients. Check renal function and electrolytes if the patient is elderly or has kidney disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel cleansing causes fluid and electrolyte losses, which with an ACE inhibitor increases the risk of acute kidney injury and hypotension. Electrolyte disturbances may also contribute to arrhythmia.
How serious is the interaction between Benazepril and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encourage adequate fluid intake before and after the preparation and consider holding benazepril on the day of use in at-risk patients. Check renal function and electrolytes if the patient is elderly or has kidney disease.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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