Drug interactions
Benazepril + Zotepine
Severity: Moderate
Benazepril and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine, an antipsychotic with alpha-1 blocking activity, can cause orthostatic hypotension, and this may be amplified by benazepril. Hypotension is most likely at treatment start or when doses are raised.
What this interaction means in plain words
Benazepril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-1 adrenergic blockade by zotepine adds to the vasodilatory and blood pressure-lowering effects of ACE inhibition.
What to do
Titrate zotepine slowly and monitor standing and sitting blood pressure. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Zotepine?
MediHelp rates the interaction as moderate. Benazepril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine, an antipsychotic with alpha-1 blocking activity, can cause orthostatic hypotension, and this may be amplified by benazepril. Hypotension is most likely at treatment start or when doses are raised.
How serious is the interaction between Benazepril and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate zotepine slowly and monitor standing and sitting blood pressure. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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