Drug interactions
Bendamustine + Cimetidine
Severity: Minor
Bendamustine and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendamustine is partly metabolized by CYP1A2 and cimetidine can inhibit this enzyme. The effect on exposure to parent drug and active metabolites is uncertain and likely small.
What this interaction means in plain words
Bendamustine and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits CYP1A2, which may alter bendamustine metabolism.
What to do
No empirical dose change is needed. Monitor hematologic parameters and toxicity as per usual bendamustine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Bendamustine
Frequently asked questions
Can I take Bendamustine with Cimetidine?
MediHelp rates the interaction as minor. Bendamustine and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bendamustine is partly metabolized by CYP1A2 and cimetidine can inhibit this enzyme. The effect on exposure to parent drug and active metabolites is uncertain and likely small.
How serious is the interaction between Bendamustine and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor hematologic parameters and toxicity as per usual bendamustine care.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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