Drug interactions
Bendamustine + Ciprofloxacin
Severity: Moderate
Bendamustine and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendamustine is partly metabolized by CYP1A2, and ciprofloxacin is a strong CYP1A2 inhibitor. Co-administration may raise bendamustine concentrations and lower those of its active metabolites, with uncertain effects on efficacy and toxicity.
What this interaction means in plain words
Bendamustine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bendamustine belongs to Oncology; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP1A2-mediated bendamustine metabolism by ciprofloxacin.
What to do
Where possible choose an antibiotic that does not inhibit CYP1A2. If combined, monitor for myelosuppression and infection and for reduced treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Bendamustine
Frequently asked questions
Can I take Bendamustine with Ciprofloxacin?
MediHelp rates the interaction as moderate. Bendamustine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bendamustine is partly metabolized by CYP1A2, and ciprofloxacin is a strong CYP1A2 inhibitor. Co-administration may raise bendamustine concentrations and lower those of its active metabolites, with uncertain effects on efficacy and toxicity.
How serious is the interaction between Bendamustine and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an antibiotic that does not inhibit CYP1A2. If combined, monitor for myelosuppression and infection and for reduced treatment response.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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