Drug interactions
Bendroflumethiazide + Budesonide-formoterol
Severity: Moderate
Bendroflumethiazide and Budesonide-formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol and thiazide diuretics can each lower serum potassium, and together the hypokalemia may be more pronounced. Low potassium raises the risk of arrhythmias, particularly in patients with cardiac disease or hypoxia. The effect is mostly relevant with higher beta-agonist doses.
What this interaction means in plain words
Bendroflumethiazide and Budesonide-formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 agonist-driven intracellular potassium shift plus thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, especially at the start of therapy or when beta-agonist use increases. Replace potassium or add a potassium-sparing agent if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Bendroflumethiazide with Budesonide-formoterol?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Budesonide-formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol and thiazide diuretics can each lower serum potassium, and together the hypokalemia may be more pronounced. Low potassium raises the risk of arrhythmias, particularly in patients with cardiac disease or hypoxia. The effect is mostly relevant with higher beta-agonist doses.
How serious is the interaction between Bendroflumethiazide and Budesonide-formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially at the start of therapy or when beta-agonist use increases. Replace potassium or add a potassium-sparing agent if levels fall.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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