Drug interactions
Bendroflumethiazide + Candesartan-hydrochlorothiazide
Severity: Major
Bendroflumethiazide and Candesartan-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a duplication of thiazide diuretic therapy, since the product already contains hydrochlorothiazide. It increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and renal impairment, with no clear added benefit.
What this interaction means in plain words
Bendroflumethiazide and Candesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effect from two thiazide diuretics acting on the distal tubule sodium-chloride cotransporter.
What to do
Avoid combining two thiazides and stop one of them. If diuretic intensification is needed, consider a different class and monitor electrolytes and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Bendroflumethiazide with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Bendroflumethiazide and Candesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This is a duplication of thiazide diuretic therapy, since the product already contains hydrochlorothiazide. It increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and renal impairment, with no clear added benefit.
How serious is the interaction between Bendroflumethiazide and Candesartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides and stop one of them. If diuretic intensification is needed, consider a different class and monitor electrolytes and renal function.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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