Drug interactions
Bendroflumethiazide + Captopril-hydrochlorothiazide
Severity: Major
Bendroflumethiazide and Captopril-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendroflumethiazide is a thiazide diuretic that duplicates the hydrochlorothiazide already in the combination product. This increases the risk of hypokalemia, hyponatremia, volume depletion, hypotension, and renal impairment without added benefit.
What this interaction means in plain words
Bendroflumethiazide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Therapeutic duplication of thiazide diuretic effects with additive electrolyte loss and volume depletion, amplified by ACE inhibition.
What to do
Avoid using two thiazide diuretics together and stop one of them. If intentional, monitor electrolytes, renal function, and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Bendroflumethiazide with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as major. Bendroflumethiazide and Captopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bendroflumethiazide is a thiazide diuretic that duplicates the hydrochlorothiazide already in the combination product. This increases the risk of hypokalemia, hyponatremia, volume depletion, hypotension, and renal impairment without added benefit.
How serious is the interaction between Bendroflumethiazide and Captopril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide diuretics together and stop one of them. If intentional, monitor electrolytes, renal function, and blood pressure closely.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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