Drug interactions
Bendroflumethiazide + Celecoxib
Severity: Moderate
Bendroflumethiazide and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effects of thiazides through sodium and water retention. In volume-depleted or older patients, the combination may also increase the risk of acute kidney injury.
What this interaction means in plain words
Bendroflumethiazide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces natriuresis and renal perfusion, opposing thiazide action.
What to do
Monitor blood pressure, fluid status and renal function. Ensure adequate hydration and adjust the diuretic dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Bendroflumethiazide with Celecoxib?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effects of thiazides through sodium and water retention. In volume-depleted or older patients, the combination may also increase the risk of acute kidney injury.
How serious is the interaction between Bendroflumethiazide and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function. Ensure adequate hydration and adjust the diuretic dose if control worsens.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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