Drug interactions
Bendroflumethiazide + Dapagliflozin-metformin
Severity: Minor
Bendroflumethiazide and Dapagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may reduce the effectiveness of antidiabetic drugs, mainly at higher doses. Volume depletion may also add to the effects of dapagliflozin.
What this interaction means in plain words
Bendroflumethiazide and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides cause hypokalemia and impaired insulin secretion and sensitivity, opposing glucose-lowering therapy.
What to do
Monitor glucose control and potassium after starting or increasing the thiazide dose. Watch for volume depletion because of the combined diuretic effect with dapagliflozin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Bendroflumethiazide with Dapagliflozin-metformin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may reduce the effectiveness of antidiabetic drugs, mainly at higher doses. Volume depletion may also add to the effects of dapagliflozin.
How serious is the interaction between Bendroflumethiazide and Dapagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control and potassium after starting or increasing the thiazide dose. Watch for volume depletion because of the combined diuretic effect with dapagliflozin.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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