Drug interactions
Bendroflumethiazide + Enalapril-hydrochlorothiazide
Severity: Moderate
Bendroflumethiazide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are thiazide diuretics, so combining them duplicates therapy and increases the risk of hypokalemia, hyponatremia, volume depletion and renal impairment without clear benefit.
What this interaction means in plain words
Bendroflumethiazide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubular sodium-chloride cotransporter.
What to do
Avoid concurrent use of two thiazides; if unavoidable, monitor electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Bendroflumethiazide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are thiazide diuretics, so combining them duplicates therapy and increases the risk of hypokalemia, hyponatremia, volume depletion and renal impairment without clear benefit.
How serious is the interaction between Bendroflumethiazide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides; if unavoidable, monitor electrolytes and renal function.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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