Drug interactions
Bendroflumethiazide + Etodolac
Severity: Moderate
Bendroflumethiazide and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effect of thiazides by promoting sodium and fluid retention. Together they may also raise the risk of acute kidney injury, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Bendroflumethiazide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, antagonizing diuretic action.
What to do
Monitor blood pressure, fluid status, and renal function, particularly at initiation; use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Bendroflumethiazide with Etodolac?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effect of thiazides by promoting sodium and fluid retention. Together they may also raise the risk of acute kidney injury, especially in volume-depleted or elderly patients.
How serious is the interaction between Bendroflumethiazide and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, and renal function, particularly at initiation; use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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