Drug interactions
Bendroflumethiazide + Fosinopril-hydrochlorothiazide
Severity: Moderate
Bendroflumethiazide and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bendroflumethiazide is a second thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypotension and volume depletion without clear added benefit.
What this interaction means in plain words
Bendroflumethiazide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication with additive inhibition of the distal tubule sodium-chloride cotransporter and potassium loss.
What to do
Avoid using two thiazides together; stop one. If unavoidable, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Bendroflumethiazide with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bendroflumethiazide is a second thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypotension and volume depletion without clear added benefit.
How serious is the interaction between Bendroflumethiazide and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together; stop one. If unavoidable, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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