Drug interactions
Bendroflumethiazide + Glyburide
Severity: Minor
Bendroflumethiazide and Glyburide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce potassium, which may weaken the effect of glyburide. The effect is dose related and usually small at low doses.
What this interaction means in plain words
Bendroflumethiazide and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides impair insulin secretion and glucose tolerance, partly via potassium loss, opposing sulfonylurea action.
What to do
Monitor blood glucose and potassium when a thiazide is started or its dose increased. Adjust the glyburide dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Bendroflumethiazide with Glyburide?
MediHelp rates the interaction as minor. Bendroflumethiazide and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and reduce potassium, which may weaken the effect of glyburide. The effect is dose related and usually small at low doses.
How serious is the interaction between Bendroflumethiazide and Glyburide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when a thiazide is started or its dose increased. Adjust the glyburide dose if control worsens.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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