Drug interactions
Bendroflumethiazide + Indomethacin
Severity: Moderate
Bendroflumethiazide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can blunt the diuretic and antihypertensive effects of thiazides and promote sodium and fluid retention. In susceptible patients such as the elderly or those with volume depletion, the combination can also increase the risk of acute kidney injury.
What this interaction means in plain words
Bendroflumethiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and sodium excretion, which opposes thiazide action.
What to do
Monitor blood pressure, fluid status, weight and renal function. Use the lowest effective indomethacin dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Bendroflumethiazide with Indomethacin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can blunt the diuretic and antihypertensive effects of thiazides and promote sodium and fluid retention. In susceptible patients such as the elderly or those with volume depletion, the combination can also increase the risk of acute kidney injury.
How serious is the interaction between Bendroflumethiazide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, weight and renal function. Use the lowest effective indomethacin dose for the shortest time.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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