Drug interactions
Bendroflumethiazide + Irbesartan
Severity: Minor
Bendroflumethiazide and Irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and angiotensin receptor blockers are commonly combined for additive blood pressure control. The ARB offsets thiazide-induced potassium loss, but hypotension and renal function changes can occur at initiation, particularly with volume depletion.
What this interaction means in plain words
Bendroflumethiazide and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects, with opposing effects on potassium.
What to do
Monitor blood pressure, electrolytes and creatinine after starting or changing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bendroflumethiazide and Irbesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Irbesartan?
MediHelp rates the interaction as minor. Bendroflumethiazide and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and angiotensin receptor blockers are commonly combined for additive blood pressure control. The ARB offsets thiazide-induced potassium loss, but hypotension and renal function changes can occur at initiation, particularly with volume depletion.
How serious is the interaction between Bendroflumethiazide and Irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and creatinine after starting or changing doses.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
