Drug interactions
Bendroflumethiazide + Methoxsalen
Severity: Moderate
Bendroflumethiazide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of phototoxic reactions such as severe sunburn.
What this interaction means in plain words
Bendroflumethiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitizing effects.
What to do
Counsel strict photoprotection and review UVA dosing. Consider an alternative antihypertensive or diuretic if phototoxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Bendroflumethiazide with Methoxsalen?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of phototoxic reactions such as severe sunburn.
How serious is the interaction between Bendroflumethiazide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict photoprotection and review UVA dosing. Consider an alternative antihypertensive or diuretic if phototoxicity occurs.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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