Drug interactions
Fedratinib + Methoxsalen
Severity: Major
Fedratinib and Methoxsalen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and CYP2C19, and methoxsalen inhibits several CYP enzymes. Higher fedratinib exposure could increase toxicity, including gastrointestinal effects, myelosuppression and the risk of encephalopathy.
What this interaction means in plain words
Fedratinib and Methoxsalen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Methoxsalen belongs to Anti Fungals.
Why it happens
Methoxsalen inhibition of CYP3A4 and CYP2C19 may reduce fedratinib clearance.
What to do
Avoid the combination where possible. If it cannot be avoided, monitor blood counts and neurological status closely and consider reducing the fedratinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Methoxsalen Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Methoxsalen?
MediHelp rates the interaction as major. Fedratinib and Methoxsalen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is metabolized by CYP3A4 and CYP2C19, and methoxsalen inhibits several CYP enzymes. Higher fedratinib exposure could increase toxicity, including gastrointestinal effects, myelosuppression and the risk of encephalopathy.
How serious is the interaction between Fedratinib and Methoxsalen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, monitor blood counts and neurological status closely and consider reducing the fedratinib dose.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Pirfenidone. The full list is on the Methoxsalen page.
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